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February Research Ethics Consortium

February 17, 2017 @ 12:30 pm - 2:00 pm

Ethical Considerations in Pragmatic Cluster Randomized Trials
Reducing health care-associated infection is imperative, but approaches vary.  In this pragmatic, comparative-effectiveness, cluster-randomized trial (CRT), multiple hospitals were randomly assigned to three different strategies to assess which was most effective in reducing ICU-attributable MRSA-positive clinical cultures.

Discussion will include issues Research Ethics Committees and Investigators contend with when reviewing and conducting CRTs and implementation research.  How should regulatory and ethical informed consent requirements be handled?  Does obtaining informed consent produce biased research?  How does variability in review affect multi-site CRTs?


Elizabeth Hohmann, MD   Associate Professor of Medicine, Harvard Medical School
Chair and Physician Director, Partners Human Research Committees
Staff Physician, Infectious Diseases Division, Massachusetts General Hospital

Richard Platt, MD, MSc   
Professor and Chair of the Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute

Spencer Hey, PhD    Research Fellow in Medicine, Harvard Medical School
Brigham and Women’s Hospital

Christine Mitchell, RN, MS, MTS   Executive Director, Harvard Medical School Center for Bioethics

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Countway Library, Minot Room
10 Shattuck St #3
Boston, MA 02115 United States
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